What is the Rosuvastatin calcium?

Rosuvastatin calcium is white to off-white crystalline solid, while it's Molecular Formula is 2(C22H27FN3O6S) . Ca. white to off-white crystalline solid antirheumatic

What is the CAS number for Rosuvastatin calcium?

The CAS number of Rosuvastatin calcium is 147098-20-2.

What is Rosuvastatin calcium (147098-20-2) used for?

Rosuvastatin, one of the two new statins launched for the treatment ofhypercholesterolemia, has high hepato-selectivity and more potent inhibitory effecton HMG-CoA reductase than the previously marketed statins. In rat hepatocytes, itinhibits cholesterol biosynthesis with an IC50 of 1.12 nM, which is ～100-fold higherpotency than pravastatin. Rosuvastatin is synthesized in a 12-step sequence, entailingthe construction of a pyrimidinyl aldehyde intermediate in eight steps and subsequentintroduction of the dihydroxyheptenoate side chain via Wittig reaction with a bketophosphoranereagent and stereoselective carbonyl reduction of the resultantenone. Pharmacokinetic properties of rosuvastatin in humans, dosed at 5–80 mg, areapproximately linear with dose. Following oral administration, rosuvastatin is rapidlyabsorbed with an oral bioavailability of ～20% and tmax of ～3 h. It has a prolongedduration of action, with terminal t1/2 of ～20 h, compatible with once-daily dosing.In humans, rosuvastatin is minimally metabolized through CYP2C9 and CYP2C19,with little or no metabolism via the CYP3A4. Approximately 90% of theadministered oral dose is eliminated in the feces (92% as the parent compound)and the rest in the urine. Rosuvastatin is considered a “superstatin” due to its ability,at well-tolerated doses, to lower LDL cholesterol and triglycerides to a much greaterextent than first generation statins. In patients with hypercholesterolemia, rosuvastatintreatment at doses of 5 and 10 mg/day over 12-week period resulted in 40–43%reduction of LDL-cholesterol levels, 12–13% increase in HDL-cholesterol, and 17–19% reduction in triglycerides. In comparison, the efficacy range of LDL-cholesterolreductions by atorvastatin (10 mg/day), pravastatin (20 mg/day), and simvastatin(20 mg/day) was 28–35%. Rosuvastatin is a well-tolerated drug at doses of 1–20 mg and the most common side effects at these doses are headache, myalgia, pain andpharyngitis, which are consistent with those previously reported for statin therapy.InChI:InChI=1/2C22H27FN3O6S.Ca/c2*1-12(2)18-16(10-9-15(26)11-17(27)20(28)29)19(13-5-7-14(22)8-6-13)24-21(23-18)25(3)32(4,30)31;/h2*5-10,12,15,17,26-27H,11H2,1-4H3,(H,28,29);/q;;+2/p-2/b2*10-9+;

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147098-20-2

Product Name：Rosuvastatin Calcium
Molecular Formula：2(C₂₂H₂₇FN₃O₆S)^.Ca
Purity：99%
Molecular Weight：1001.14

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pd_meltingpoint:122 °C

Appearance:white to off-white crystalline solid

Buy Good Quality Rosuvastatin Calcium 147098-20-2 with a minimum purity of 99%

Molecular Formula:2(C22H27FN3O6S)^.Ca
Molecular Weight:1001.14
Appearance/Colour:white to off-white crystalline solid
Melting Point:122 °C
Boiling Point:745.6 °C at 760 mmHg
Flash Point:404.7 °C
PSA：304.26000
Density:==
LogP:4.29560

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Buy Good Quality Rosuvastatin Calcium 147098-20-2 with a minimum purity of 99%

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