Lupeol is white powder, while it's Molecular Formula is C30H50O. white powder Lupeol was used as reference standard in method development and validation of lupeol from Vernonia Cinerea using HPLC method. It has been used as a standard for the identification and quantification of triterpenoids in blueberry cuticular wax by GC.

What is the CAS number for Lupeol?

The CAS number of Lupeol is 545-47-1.

What is Lupeol (545-47-1) used for?

Lupeol is a kind of novel anti-inflammatory and anti-cancer dietary triterpene that can be found in white cabbage, green pepper, strawberry, olive, mangoes and grapes. In recent years, much progress has been made on the application of this molecule for clinical treatment of various kind of disorders. On the one hand, it has been extensively studied that it is capable of inhibiting inflammation under both in vitro and in animal models. Studies have shown that Lupeol is a multi-target agent during its anti-inflammation effect, targeting on many key molecular pathways involving nuclear factor kappa B (NFκB), cFLIP, Fas, Kras, phosphatidylinositol-3-kinase (PI3K)/Akt and Wnt/β-catenin. On the other hand, Lupeol has strong anti-tumor effect during treatment of various cancer types such as prostate, skin, pancreatic and breast cancer. The anti-tumor effect might be related to its potential to modulate important signaling pathways such as nuclear factor kappa B (NFκB) and the phosphatidylinositol 3-kinase [PI3K] /Akt (protein kinase B pathway), which are crucial during tumorigenesis.InChI:InChI=1/C30H50O/c1-19(2)20-11-14-27(5)17-18-29(7)21(25(20)27)9-10-23-28(6)15-13-24(31)26(3,4)22(28)12-16-30(23,29)8/h20-25,31H,1,9-18H2,2-8H3/t20-,21+,22-,23+,24-,25+,27+,28-,29+,30+/m0/s1

Lupeol is white powder, while it's Molecular Formula is C30H50O. white powder Lupeol was used as reference standard in method development and validation of lupeol from Vernonia Cinerea using HPLC method. It has been used as a standard for the identification and quantification of triterpenoids in blueberry cuticular wax by GC.

What is the CAS number for Lupeol?

The CAS number of Lupeol is 545-47-1.

What is Lupeol (545-47-1) used for?

Lupeol is a kind of novel anti-inflammatory and anti-cancer dietary triterpene that can be found in white cabbage, green pepper, strawberry, olive, mangoes and grapes. In recent years, much progress has been made on the application of this molecule for clinical treatment of various kind of disorders. On the one hand, it has been extensively studied that it is capable of inhibiting inflammation under both in vitro and in animal models. Studies have shown that Lupeol is a multi-target agent during its anti-inflammation effect, targeting on many key molecular pathways involving nuclear factor kappa B (NFκB), cFLIP, Fas, Kras, phosphatidylinositol-3-kinase (PI3K)/Akt and Wnt/β-catenin. On the other hand, Lupeol has strong anti-tumor effect during treatment of various cancer types such as prostate, skin, pancreatic and breast cancer. The anti-tumor effect might be related to its potential to modulate important signaling pathways such as nuclear factor kappa B (NFκB) and the phosphatidylinositol 3-kinase [PI3K] /Akt (protein kinase B pathway), which are crucial during tumorigenesis.InChI:InChI=1/C30H50O/c1-19(2)20-11-14-27(5)17-18-29(7)21(25(20)27)9-10-23-28(6)15-13-24(31)26(3,4)22(28)12-16-30(23,29)8/h20-25,31H,1,9-18H2,2-8H3/t20-,21+,22-,23+,24-,25+,27+,28-,29+,30+/m0/s1

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545-47-1

Product Name：Lupeol
Molecular Formula：C₃₀H₅₀O
Purity：99%
Molecular Weight：426.726

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Product Details

pd_meltingpoint:215-216oC

Appearance:white powder

Purity 99% Min Lupeol 545-47-1 Spot Supply with Safe Transportation

Molecular Formula:C30H50O
Molecular Weight:426.726
Appearance/Colour:white powder
Vapor Pressure:1.41E-11mmHg at 25°C
Melting Point:215-216oC
Refractive Index:1.515
Boiling Point:488.1 °C at 760 mmHg
PKA:15.19±0.70(Predicted)
Flash Point:216.9 °C
PSA：20.23000
Density:0.978 g/cm³
LogP:8.02480

Lupeol(Cas 545-47-1) Usage

Definition	ChEBI: A pentacyclic triterpenoid that is lupane in which the hydrogen at the 3beta position is substituted by a hydroxy group. It occurs in the skin of lupin seeds, as well as in the latex of fig trees and of rubber plants. It is also found in m ny edible fruits and vegetables.
General Description	Lupeol is a novel anti-cancer and anti-inflammatory dietary triterpene. They help in stabilizing phospholipid bilayers in plant cell membranes. In general, this group contains 28-29 carbons along with carbon-carbon double bonds, usually one in the sterol nucleus and at times a second in the alkyl side chain.

InChI:InChI=1/C30H50O/c1-19(2)20-11-14-27(5)17-18-29(7)21(25(20)27)9-10-23-28(6)15-13-24(31)26(3,4)22(28)12-16-30(23,29)8/h20-25,31H,1,9-18H2,2-8H3/t20-,21+,22-,23+,24-,25+,27+,28-,29+,30+/m0/s1

545-47-1 Relevant articles

Pentacyclic triterpenes and naphthoquinones from Euclea divinorum

Mebe, Paul P.,Cordell, Geoffrey A.,Pezzuto, John M.

, p. 311 - 313 (1998)

Phytochemical studies on Euclea divinoru...

TRITERPENOIDS OF AMSONIA GRANDIFLORA

Wahyuono, Subagus,Hoffmann, Joseph J.,Jolad, Shivanand D.,Dentali, Steven J.

, p. 1213 (1987)

Stems and leaves of Amsonia grandiflora ...

Antibacterial activity of naphthoquinones and triterpenoids from Euclea natalensis root bark

Weigenand, Oliver,Hussein, Ahmed A.,Lall, Namrita,Meyer, Jacobus J. M.

, p. 1936 - 1938 (2004)

Phytochemical studies of an ethanolic ex...

Synthesis of Lupeol from Betulin

Garifullina,Myasoedova, Yu. V.,Ishmuratova

, p. 765 - 767 (2019/08/07)

Practical Synthesis of α-Amyrin, β-Amyrin, and Lupeol: The Potential Natural Inhibitors of Human Oxidosqualene Cyclase

Chen, Dongyin,Xu, Fengguo,Zhang, Pu,Deng, Jie,Sun, Hongbin,Wen, Xiaoan,Liu, Jun

, (2017/10/20)

A practical synthesis of α-amyrin (1), β...

And reclaims to clean rough synthesis method

-

Paragraph 0036-0041; 0053-0055, (2017/08/25)

The invention belongs to the research fi...

Lupeol-3-O-decanoate, a new triterpene ester from Cadaba farinosa Forssk. growing in Saudi Arabia

Al-Musayeib, Nawal M.,Mohamed, Gamal A.,Ibrahim, Sabrin R. M.,Ross, Samir A.

, p. 5297 - 5302 (2013/12/04)

A new triterpene ester (1) together with...

545-47-1 Process route

: Pentadecanoic acid (1R,3aR,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-1-isopropenyl-3a,5a,5b,8,8,11a-hexamethyl-icosahydro-cyclopenta[a]chrysen-9-yl ester